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Reversal of Dual Antiplatelet Therapy With Cold Stored ...

Dec 27, 2018 · Each subject will donate two apheresis platelet units. One platelet unit will be stored in the cold (CSP) and one platelet unit will be stored at room temperature (RTP). Subjects will be given dual anti-platelet therapy (aspirin and clopidogrel) prior to autologous transfusion of each unit.

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Anti-platelet therapy holds promises in treating ...

Oct 10, 2016 · Anti-platelet treatment is efficacious in suppression of myometrial infiltration, improving generalized hyperalgesia, reducing uterine hyperactivity and systemic corticosterone levels. Collectively, these results demonstrate that anti-platelet therapy seems to be promising for treating adenomyosis.

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Anti-platelet activity of panaxatriol saponins is mediated ...

Increased platelet aggregation is implicated in the pathogenesis of ischemic stroke and anti-platelet strategy may contribute to its therapy. Panaxatriol saponin (PTS), the main components extracted from Panax notoginseng, has been shown to be efficacious in the prevention and treatment of ischemic stroke in China. The aim of this study is to determine the anti-platelet activity and explore ...

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Anti-platelet therapy holds promises in treating ...

Oct 10, 2016 · Anti-platelet treatment is efficacious in suppression of myometrial infiltration, improving generalized hyperalgesia, reducing uterine hyperactivity and systemic corticosterone levels. Collectively, these results demonstrate that anti-platelet therapy seems to be promising for treating adenomyosis.

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Differing effect of systemic anti psoriasis therapies on ...

Therefore anti TNFs might normalize platelet counts through the reduction of circulating IL-6 levels. Furthermore, increased platelet activation and aggregation have been demonstrated to be the features of IBD and has been proposed to contribute to the pathogenesis of .

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Design, Synthesis and Anti-Platelet Aggregation Activity ...

Ginkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules. A series of ginkgolide-1,2,3-triazole conjugates with varied functional groups including benzyl, phenyl and heterocycle moieties was thus synthesized.

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Binding of anti–platelet factor 4/heparin antibodies ...

Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4. Martin Kreimann, Sven Brandt, Krystin Krauel, Stephan Block, Christiane A. Helm, Werner Weitschies, Andreas Greinacher and Mihaela Delcea. ... OpenUrl Abstract / FREE Full Text ...

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When to stop anticoagulation, anti-platelet aggregates ...

The anti-platelet aggregates include: Aspirin/Clopidogrel (stop >7-10 days preoperatively). The ple NSAIDs should be stopped for varying intervals ranging from 1-10 days prior to spine surgery, and increase bleeding risks when combined with any of the anticoagulants or anti-platelet aggregates.

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Efficacy and safety of adding rivaroxaban to the anti ...

May 02, 2018 · Rivaroxaban, a direct factor Xa inhibitor, has seldom been used in patients with coronary artery disease. In this analysis, we aimed to systematically compare the efficacy and safety of rivaroxaban in addition to the anti-platelet regimen in patients with coronary artery disease. Online databases (MEDLINE, EMBASE, Cochrane database, and Google scholar were .

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Antiplatelet Drugs - Prices and Information - GoodRx

Prasugrel (Effient) is an expensive drug used to prevent heart attack, stroke, or other vascular events in people who are at high risk.This drug is slightly less popular than comparable drugs. Effient is available in both brand and generic versions. It is covered by most Medicare and insurance plans, but some manufacturer and pharmacy coupons can still help offset the cost.

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[Full text] Anti-platelet effects of anti-glaucomatous eye ...

Jan 04, 2017 · Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets Marilita M Moschos,1,2 Giannis A Moustafa,1 Vasiliki D Papakonstantinou,3 Michael Tsatsos,4 Konstantinos Laios,1 Smaragdi Antonopoulou3 11st Department of Ophthalmology, Medical School, University of Athens, Athens, Greece; 2Biomedical Research Foundation, Academy of Athens, Athens, .

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Detection of anti-platelet antibodies in patients with ...

The ELISA procedure as applied to detect anti-platelet antibodies in patients with herpes or rubella viral infections and in patients with idiopathic thrombocytopenic purpura (ITP). Twenty-eight sera from 13 thrombocytopenic patients showed high levels of anti-platelet antibodies. ... Full text Full text is available as a scanned copy of the ...

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Antiplatelet | definition of antiplatelet by Medical ...

an·ti·plate·let (an'tē-plāt'let), A substance that manifests a lytic or agglutinative action on blood platelets, thereby inhibiting or destroying the effects of the latter. antiplatelet (ăn′tē-plāt′lĭt, ăn′tī-) adj. Acting against or destroying blood platelets. antiplatelet [-plat′lit] any agent that destroys platelets or inhibits ...

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Platelet desialylation correlates with efficacy of first ...

Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is still unavailable. Using murine models and in vitro studies of human blood samples, we recently identified a novel Fc-independent platelet clearance pathway, whereby antibody-mediated ...

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Platelets | ScienceDirect

Future directions of importance in the field include increasing sample size and phenotyping breadth for platelet function genetics, translating discoveries into mechanistic models, further searches for genes relevant in anti-platelet treatment contexts, and application of integrative omics (e.g., transcriptomes, proteomes) strategies.

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Anti-platelet Effect of Berberine in Patients After ...

Dec 20, 2017 · The APLABE-PCI is a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, which is designed to assess the anti-platelet effect of berberine in approximately 64 patients receiving aspirin and clopidogrel who are at > 8 but ≤ 40 weeks after elective percutaneous coronary intervention for stable coronary ...

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Platelet-membrane-biomimetic nanoparticles for targeted ...

Nanoscale drug-delivery systems (DDSs) have great promise in tumor diagnosis and treatment. Platelet membrane (PLTM) biomimetic DDSs are expected to enhance retention in vivo and escape uptake by macrophages, as well as minimizing immunogenicity, attributing to the CD47 protein in PLTM sends "don't eat me" signals to macrophages. In addition, P-selectin is overexpressed on the PLTM ...

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antiplatelet - Wiktionary

Feb 19, 2019 · (immunology) Working against or destroying blood platelets.··A drug that destroys blood platelets. 2015 July 31, Ying Xian et al., "Real world effectiveness of warfarin among ischemic stroke patients with atrial fibrillation: observational analysis from Patient-Centered Research into Outcomes Stroke Patients Prefer and Effectiveness Research ...

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Platelets, diabetes and myocardial ischemia/reperfusion injury

We also treat the influence of T2DM on ischemia/reperfusion injury and how anti-platelet therapies affect post-ischemic myocardial damage through pleiotropic properties not related to their anti-aggregating effects. miRNA-based signature associated with T2DM and its cardiovascular disease complications are also briefly considered.

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Anti‐platelet therapy in small animal medicine - Thomason ...

While the role of the platelet in pathologic thrombus formation is not fully understood, veterinarians often resort to anti‐platelet therapy in the management of patients at risk for thromboembolic complications, because many anti‐platelet medications are inexpensive, .

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